{"id":3,"date":"2023-01-03T12:34:34","date_gmt":"2023-01-03T12:34:34","guid":{"rendered":"https:\/\/pressbooks.justwrite.in\/mitochondrial-inheritance\/?p=3"},"modified":"2023-03-03T15:15:17","modified_gmt":"2023-03-03T15:15:17","slug":"main-body","status":"publish","type":"part","link":"https:\/\/pressbooks.justwrite.in\/mitochondrial-inheritance\/part\/main-body\/","title":{"raw":"Mitochondria","rendered":"Mitochondria"},"content":{"raw":"Mitochondria are cellular organelles that are located outside of the nucleus in the cytoplasm. There are many thousands of mitochondria within each cell, especially in muscle and brain. Mitochondria play a central role in energy metabolism. Mitochondria are often referred to as<span>\u00a0<\/span><strong><em>the powerhouse of the cell<\/em><span>\u00a0<\/span><\/strong>as they are the main source of cellular ATP production via\u00a0 \u00a0 \u00a0 \u00a0 \u00a0oxidative phosphorylation, that takes place in the inner mitochondrial membrane through the <strong>Electron Transport Chain.<\/strong>\r\n\r\n[h5p id=\"1\"]\r\n\r\nMitochondria play an essential role in the biosynthesis of macromolecules, such as nucleotides, lipids, heme, and iron-sulfur clusters.\r\n\r\nBesides their role in metabolism both anabolism and catabolism, mitochondria regulate signals that mediate \u00a0various biological outcomes like cell death, Ca2+-homeostasis, gene\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 expression, differentiation ,cellular senescence, chronic inflammation and the age-dependent stem cell activity.\r\n\r\n<strong>Altered mitochondrial function result in pathological conditions<\/strong> like metabolic disorders, cardiomyopathies, neurodegeneration , cancer and dysregulated cell death","rendered":"<p>Mitochondria are cellular organelles that are located outside of the nucleus in the cytoplasm. There are many thousands of mitochondria within each cell, especially in muscle and brain. Mitochondria play a central role in energy metabolism. Mitochondria are often referred to as<span>\u00a0<\/span><strong><em>the powerhouse of the cell<\/em><span>\u00a0<\/span><\/strong>as they are the main source of cellular ATP production via\u00a0 \u00a0 \u00a0 \u00a0 \u00a0oxidative phosphorylation, that takes place in the inner mitochondrial membrane through the <strong>Electron Transport Chain.<\/strong><\/p>\n<div id=\"h5p-1\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-1\" class=\"h5p-iframe\" data-content-id=\"1\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"Mitochondrial DNA\"><\/iframe><\/div>\n<\/div>\n<p>Mitochondria play an essential role in the biosynthesis of macromolecules, such as nucleotides, lipids, heme, and iron-sulfur clusters.<\/p>\n<p>Besides their role in metabolism both anabolism and catabolism, mitochondria regulate signals that mediate \u00a0various biological outcomes like cell death, Ca2+-homeostasis, gene\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 expression, differentiation ,cellular senescence, chronic inflammation and the age-dependent stem cell activity.<\/p>\n<p><strong>Altered mitochondrial function result in pathological conditions<\/strong> like metabolic disorders, cardiomyopathies, neurodegeneration , cancer and dysregulated cell death<\/p>\n","protected":false},"parent":0,"menu_order":1,"template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"pb_part_invisible":false,"pb_part_invisible_string":""},"contributor":[],"license":[],"class_list":["post-3","part","type-part","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/pressbooks.justwrite.in\/mitochondrial-inheritance\/wp-json\/pressbooks\/v2\/parts\/3","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pressbooks.justwrite.in\/mitochondrial-inheritance\/wp-json\/pressbooks\/v2\/parts"}],"about":[{"href":"https:\/\/pressbooks.justwrite.in\/mitochondrial-inheritance\/wp-json\/wp\/v2\/types\/part"}],"version-history":[{"count":4,"href":"https:\/\/pressbooks.justwrite.in\/mitochondrial-inheritance\/wp-json\/pressbooks\/v2\/parts\/3\/revisions"}],"predecessor-version":[{"id":209,"href":"https:\/\/pressbooks.justwrite.in\/mitochondrial-inheritance\/wp-json\/pressbooks\/v2\/parts\/3\/revisions\/209"}],"wp:attachment":[{"href":"https:\/\/pressbooks.justwrite.in\/mitochondrial-inheritance\/wp-json\/wp\/v2\/media?parent=3"}],"wp:term":[{"taxonomy":"contributor","embeddable":true,"href":"https:\/\/pressbooks.justwrite.in\/mitochondrial-inheritance\/wp-json\/wp\/v2\/contributor?post=3"},{"taxonomy":"license","embeddable":true,"href":"https:\/\/pressbooks.justwrite.in\/mitochondrial-inheritance\/wp-json\/wp\/v2\/license?post=3"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}