{"id":309,"date":"2024-03-23T10:03:17","date_gmt":"2024-03-23T10:03:17","guid":{"rendered":"https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/?post_type=chapter&#038;p=309"},"modified":"2024-11-18T13:14:36","modified_gmt":"2024-11-18T13:14:36","slug":"6-3-phylogenetics","status":"publish","type":"chapter","link":"https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/chapter\/6-3-phylogenetics\/","title":{"raw":"7.3 Phylogenetics","rendered":"7.3 Phylogenetics"},"content":{"raw":"<div class=\"flex-shrink-0 flex flex-col relative items-end\">\r\n<div>\r\n<div class=\"pt-0\">\r\n<div class=\"gizmo-bot-avatar flex h-8 w-8 items-center justify-center overflow-hidden rounded-full\">\r\n<div class=\"relative p-1 rounded-sm flex items-center justify-center bg-token-main-surface-primary text-token-text-primary h-8 w-8\"><\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<div class=\"group\/conversation-turn relative flex w-full min-w-0 flex-col agent-turn\">\r\n<div class=\"flex-col gap-1 md:gap-3\">\r\n<div class=\"flex max-w-full flex-col flex-grow\">\r\n<div data-message-author-role=\"assistant\" data-message-id=\"ab00fa80-f883-49e8-8d8a-cf08b58d7197\" dir=\"auto\" class=\"min-h-8 text-message flex w-full flex-col items-end gap-2 whitespace-normal break-words [.text-message+&amp;]:mt-5\" data-message-model-slug=\"gpt-4o\">\r\n<div class=\"flex w-full flex-col gap-1 empty:hidden first:pt-[3px]\">\r\n<div class=\"markdown prose w-full break-words dark:prose-invert light\">\r\n\r\nThe study of evolutionary relationships among organisms is called Phylogenetics.\u00a0It reconstructs the evolutionary history of species and charts their relationships in a phylogenetic tree using genetic, morphological, and biochemical data. Understanding the relationships between species, the history of their evolutionary divergence, and the evolution of features across time is made easier by phylogenetics.\r\n<h2><strong>Phylogenetic Trees<\/strong><\/h2>\r\nTo illustrate the evolutionary relationships and paths between organisms, scientists employ a particular kind of model known as a <strong>phylogenetic tree<\/strong>\u00a0 also called as <strong>evolutionary trees.<\/strong> It is an illustration of the evolutionary links between individuals or groups of organisms\u00a0 . As the suggested linkages cannot be verified in the past, scientists view phylogenetic trees as a hypothesis of the evolutionary past.\r\n<h2>Terminology that characterizes a phylogenetic tree.<\/h2>\r\n<div>The lines in the tree are called<strong> branches. <strong style=\"font-size: 1em\">Branches<\/strong><span style=\"font-size: 1em\"> on the tree indicate lineages of organisms. <\/span><\/strong><span style=\"font-size: 1em\">At the tips of the branches are present-day species or sequences known as taxa (the singular form is taxon) or operational taxonomic units.<\/span>The connecting point where two adjacent branches join ( branch point) is called a <strong>node<\/strong>, which represents <span style=\"font-size: 1em\">a common ancestor.<span>In a phylogenetic tree, closely related organisms are joined by nodes. These nodes suggest common ancestry.\u00a0 two taxa stemming from the same most recent node are called\u00a0<strong> sister taxa.<\/strong><\/span><\/span><\/div>\r\n<div><\/div>\r\n<div><strong style=\"text-align: initial;font-size: 1em\">Rooted and Unrooted trees\u00a0<\/strong><\/div>\r\nA common ancestor is represented by a single lineage at the base of many phylogenetic trees. Such trees are referred\u00a0 as <strong>rooted phylogenetic tree<\/strong>, indicating that all of the creatures shown in the diagram are related to a single ancestral lineage, usually drawn from the bottom or left. The three domains of bacteria, archaea, and eukarya branch off from a single point in the rooted phylogenetic tree.In this image, the little branch that plants and animals\u2014including humans\u2014occupy demonstrates how recent and insignificant these groupings are in relation to other species.<strong> Unrooted\u00a0 phylogenetic trees<\/strong> reveal links between species but not a common ancestor.\r\n\r\n<img src=\"http:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-content\/uploads\/sites\/24\/2024\/03\/Picture1-300x106.png\" alt=\"\" width=\"300\" height=\"106\" class=\"size-medium wp-image-1655 aligncenter\" \/>\r\n\r\n<strong>Clade or monophyletic group\u00a0<\/strong>\r\n<div>A group of taxa descended from a single common ancestor is defined as a <strong>clade or monophyletic group. <\/strong>In a monophyletic group, two taxa share a unique common ancestor not shared by any other taxa. They are also referred to as sister taxa to each other (e.g., taxa B and C). <span style=\"text-align: initial;font-size: 1em\">Example: In mammals, the clade of primates includes humans, chimpanzees, gorillas, and all other primates with their common ancestor.<\/span>\r\nThe branch path depicting an ancestor\u2013descendant relationship on a tree is called a<strong> lineage.\u00a0<\/strong><\/div>\r\n<div><\/div>\r\n<\/div>\r\n<div><strong>Paraphyletic group<\/strong><\/div>\r\n<div class=\"markdown prose w-full break-words dark:prose-invert light\">\r\n<div>When a number of taxa share more than one closest common ancestors, they do not fit the definition of a clade.In this case, they are referred to as paraphyletic (e.g., taxa B, C, and D).<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<div><img src=\"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/8\/8c\/Taxonomy_and_phylogenetics.svg\/467px-Taxonomy_and_phylogenetics.svg.png?20200520095727\" alt=\"File:Taxonomy and phylogenetics.svg\" class=\"aligncenter\" \/><\/div>\r\n<div style=\"text-align: center\"><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Taxonomy_and_phylogenetics.svg\" target=\"_blank\" rel=\"noopener\">\"Taxonomy and Phylogenetics\"<\/a><span>\u00a0by\u00a0<\/span><a>BoldLuis via Creative commons .org via wikimedia commons<\/a><span>is licensed under\u00a0<\/span><a href=\"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0\" target=\"_blank\" rel=\"noopener\">CC BY-SA 4.0<\/a><\/div>\r\n<h2><strong>Tree topology<\/strong><\/h2>\r\n<div>\r\n<div>The branching pattern in a tree is called <strong>tree topology. <\/strong>When all branches bifurcate on a phylogenetic tree, it is referred to as <strong>dichotomy. <\/strong>In this case, each ancestor divides and gives rise to two descendants.<\/div>\r\n<div>Sometimes, a branch point on a phylogenetic tree may have more than two descendents, resulting in a multifurcating node. The phylogeny with multifurcating branches is called <strong>polytomy. <\/strong>A polytomy can be a result of either an ancestral taxon giving rise to more than two immediate descendants simultaneously during evolution, a process known as radiation, or\u00a0 <span style=\"font-size: 1em\">\u00a0an unresolved phylogeny in which the exact order of bifurcations cannot be determined precisely<\/span><\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<div><\/div>\r\n<div><\/div>\r\n<div><img src=\"http:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-content\/uploads\/sites\/24\/2024\/03\/Dichotomy-and-polytomy-300x136.png\" alt=\"\" width=\"300\" height=\"136\" class=\"size-medium wp-image-1653 aligncenter\" \/><\/div>\r\n<div class=\"group\/conversation-turn relative flex w-full min-w-0 flex-col agent-turn\">\r\n<div class=\"flex-col gap-1 md:gap-3\">\r\n<div class=\"flex max-w-full flex-col flex-grow\">\r\n<div data-message-author-role=\"assistant\" data-message-id=\"ab00fa80-f883-49e8-8d8a-cf08b58d7197\" dir=\"auto\" class=\"min-h-8 text-message flex w-full flex-col items-end gap-2 whitespace-normal break-words [.text-message+&amp;]:mt-5\" data-message-model-slug=\"gpt-4o\">\r\n<div class=\"flex w-full flex-col gap-1 empty:hidden first:pt-[3px]\">\r\n<div class=\"markdown prose w-full break-words dark:prose-invert light\">\r\n\r\n<strong>Forms of Tree Representation\u00a0<\/strong>\r\n\r\n<strong>Phylogram and Cladogram<\/strong>\r\n<div>The topology of branches in a tree defines the relationships between the taxa. The trees can be drawn in different ways, such as a cladogram or a phylogram.<\/div>\r\n<div>In a<strong> phylogram<\/strong>, the branch lengths represent the amount of evolutionary divergence. Such trees are said to be scaled.The scaled trees have the advantage of showing both the evolutionary relationships and information about the relative divergence time of the branches.<\/div>\r\n<div>In a <strong>cladogram<\/strong>, however, the external taxa line up neatly in a row or column. Their branch lengths are not proportional to the number of evolutionary changes and thus have no phylogenetic meaning. In such an unscaled tree, only the topology of the tree matters, which shows the relative ordering of the taxa.<\/div>\r\n<div><img src=\"http:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-content\/uploads\/sites\/24\/2024\/03\/Cladogram-and-Phylogram-300x185.png\" alt=\"\" width=\"300\" height=\"185\" class=\"size-medium wp-image-1658 aligncenter\" \/><\/div>\r\n<strong>Molecular Phylogenetics<\/strong>:\r\n\r\nenables researchers to track lineages back to common ancestors by analyzing evolutionary relationships using DNA, RNA, or protein sequences.\r\nMolecular techniques have transformed phylogenetics by offering information that helps elucidate connections in situations when morphological evidence is unclear or lacking.\r\n\r\n<span style=\"font-family: 'Cormorant Garamond', serif;font-size: 1.602em\">Methods of Building Phylogenetic Trees<\/span>\r\n<ol>\r\n \t<li><strong>Distance Methods<\/strong>:\r\n<ul>\r\n \t<li>These methods create a tree based on overall similarity.These techniques determine the genetic distance between two sequence pairs.<\/li>\r\n \t<li><strong>Neighbor-joining<\/strong> is a popular distance method \u00a0that reduces the tree's overall branch length.<\/li>\r\n<\/ul>\r\n<\/li>\r\n \t<li><strong>Maximum Parsimony<\/strong>:\r\n<ul>\r\n \t<li>This approach assumes that simpler evolutionary pathways are more plausible than complex ones, and it looks for the tree with the fewest evolutionary changes.<\/li>\r\n<\/ul>\r\n<\/li>\r\n \t<li><strong>Maximum Likelihood and Bayesian Methods<\/strong>:\r\n<ul>\r\n \t<li>The Bayesian and maximum likelihood statistical techniques determine the likelihood of a specific tree given an evolutionary change model.\r\nWhile Bayesian approaches predict a range of plausible topologies, Maximum Likelihood uses sequence data to determine which tree has the highest likelihood.<\/li>\r\n<\/ul>\r\n<\/li>\r\n<\/ol>\r\n<h3>Applications of Phylogenetics<\/h3>\r\n<ol>\r\n \t<li><strong>Classification and Taxonomy<\/strong>: Contributes to the improvement of the biological categorization system by grouping species according to evolutionary links.<\/li>\r\n \t<li><strong>Understanding Evolutionary History<\/strong>: The chronology and order of evolutionary events, including speciation and trait development, can be known by an understanding of evolutionary history.<\/li>\r\n \t<li><strong>Tracking Disease Evolution<\/strong>: This method is used in epidemiology to investigate the causes and dissemination of infections, including monitoring the genetic development of viruses such as SARS-CoV-2 and HIV.<\/li>\r\n \t<li><strong>Conservation Biology<\/strong>: Assists in identifying evolutionary distinct species that, because of their distinct genetic heritage, may be conservation priorities.<\/li>\r\n \t<li><strong>Comparative Genomics<\/strong>: Phylogenetics helps to compare genomes across species, identify conserved genes, and to study gene function and evolution.<\/li>\r\n<\/ol>\r\n<\/div>\r\n<h2>Test your Understanding<\/h2>\r\n<span>[h5p id=\"112\"]<\/span>\r\n\r\n&nbsp;\r\n<div class=\"markdown prose w-full break-words dark:prose-invert light\">\r\n\r\n&nbsp;\r\n\r\n&nbsp;\r\n\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>","rendered":"<div class=\"flex-shrink-0 flex flex-col relative items-end\">\n<div>\n<div class=\"pt-0\">\n<div class=\"gizmo-bot-avatar flex h-8 w-8 items-center justify-center overflow-hidden rounded-full\">\n<div class=\"relative p-1 rounded-sm flex items-center justify-center bg-token-main-surface-primary text-token-text-primary h-8 w-8\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"group\/conversation-turn relative flex w-full min-w-0 flex-col agent-turn\">\n<div class=\"flex-col gap-1 md:gap-3\">\n<div class=\"flex max-w-full flex-col flex-grow\">\n<div data-message-author-role=\"assistant\" data-message-id=\"ab00fa80-f883-49e8-8d8a-cf08b58d7197\" dir=\"auto\" class=\"min-h-8 text-message flex w-full flex-col items-end gap-2 whitespace-normal break-words [.text-message+&amp;]:mt-5\" data-message-model-slug=\"gpt-4o\">\n<div class=\"flex w-full flex-col gap-1 empty:hidden first:pt-[3px]\">\n<div class=\"markdown prose w-full break-words dark:prose-invert light\">\n<p>The study of evolutionary relationships among organisms is called Phylogenetics.\u00a0It reconstructs the evolutionary history of species and charts their relationships in a phylogenetic tree using genetic, morphological, and biochemical data. Understanding the relationships between species, the history of their evolutionary divergence, and the evolution of features across time is made easier by phylogenetics.<\/p>\n<h2><strong>Phylogenetic Trees<\/strong><\/h2>\n<p>To illustrate the evolutionary relationships and paths between organisms, scientists employ a particular kind of model known as a <strong>phylogenetic tree<\/strong>\u00a0 also called as <strong>evolutionary trees.<\/strong> It is an illustration of the evolutionary links between individuals or groups of organisms\u00a0 . As the suggested linkages cannot be verified in the past, scientists view phylogenetic trees as a hypothesis of the evolutionary past.<\/p>\n<h2>Terminology that characterizes a phylogenetic tree.<\/h2>\n<div>The lines in the tree are called<strong> branches. <strong style=\"font-size: 1em\">Branches<\/strong><span style=\"font-size: 1em\"> on the tree indicate lineages of organisms. <\/span><\/strong><span style=\"font-size: 1em\">At the tips of the branches are present-day species or sequences known as taxa (the singular form is taxon) or operational taxonomic units.<\/span>The connecting point where two adjacent branches join ( branch point) is called a <strong>node<\/strong>, which represents <span style=\"font-size: 1em\">a common ancestor.<span>In a phylogenetic tree, closely related organisms are joined by nodes. These nodes suggest common ancestry.\u00a0 two taxa stemming from the same most recent node are called\u00a0<strong> sister taxa.<\/strong><\/span><\/span><\/div>\n<div><\/div>\n<div><strong style=\"text-align: initial;font-size: 1em\">Rooted and Unrooted trees\u00a0<\/strong><\/div>\n<p>A common ancestor is represented by a single lineage at the base of many phylogenetic trees. Such trees are referred\u00a0 as <strong>rooted phylogenetic tree<\/strong>, indicating that all of the creatures shown in the diagram are related to a single ancestral lineage, usually drawn from the bottom or left. The three domains of bacteria, archaea, and eukarya branch off from a single point in the rooted phylogenetic tree.In this image, the little branch that plants and animals\u2014including humans\u2014occupy demonstrates how recent and insignificant these groupings are in relation to other species.<strong> Unrooted\u00a0 phylogenetic trees<\/strong> reveal links between species but not a common ancestor.<\/p>\n<p><img decoding=\"async\" src=\"http:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-content\/uploads\/sites\/24\/2024\/03\/Picture1-300x106.png\" alt=\"\" width=\"300\" height=\"106\" class=\"size-medium wp-image-1655 aligncenter\" srcset=\"https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-content\/uploads\/sites\/24\/2024\/03\/Picture1-300x106.png 300w, https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-content\/uploads\/sites\/24\/2024\/03\/Picture1-768x271.png 768w, https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-content\/uploads\/sites\/24\/2024\/03\/Picture1-65x23.png 65w, https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-content\/uploads\/sites\/24\/2024\/03\/Picture1-225x79.png 225w, https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-content\/uploads\/sites\/24\/2024\/03\/Picture1-350x123.png 350w, https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-content\/uploads\/sites\/24\/2024\/03\/Picture1.png 845w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p><strong>Clade or monophyletic group\u00a0<\/strong><\/p>\n<div>A group of taxa descended from a single common ancestor is defined as a <strong>clade or monophyletic group. <\/strong>In a monophyletic group, two taxa share a unique common ancestor not shared by any other taxa. They are also referred to as sister taxa to each other (e.g., taxa B and C). <span style=\"text-align: initial;font-size: 1em\">Example: In mammals, the clade of primates includes humans, chimpanzees, gorillas, and all other primates with their common ancestor.<\/span><br \/>\nThe branch path depicting an ancestor\u2013descendant relationship on a tree is called a<strong> lineage.\u00a0<\/strong><\/div>\n<div><\/div>\n<\/div>\n<div><strong>Paraphyletic group<\/strong><\/div>\n<div class=\"markdown prose w-full break-words dark:prose-invert light\">\n<div>When a number of taxa share more than one closest common ancestors, they do not fit the definition of a clade.In this case, they are referred to as paraphyletic (e.g., taxa B, C, and D).<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div><img decoding=\"async\" src=\"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/8\/8c\/Taxonomy_and_phylogenetics.svg\/467px-Taxonomy_and_phylogenetics.svg.png?20200520095727\" alt=\"File:Taxonomy and phylogenetics.svg\" class=\"aligncenter\" \/><\/div>\n<div style=\"text-align: center\"><a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Taxonomy_and_phylogenetics.svg\" target=\"_blank\" rel=\"noopener\">&#8220;Taxonomy and Phylogenetics&#8221;<\/a><span>\u00a0by\u00a0<\/span><a>BoldLuis via Creative commons .org via wikimedia commons<\/a><span>is licensed under\u00a0<\/span><a href=\"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0\" target=\"_blank\" rel=\"noopener\">CC BY-SA 4.0<\/a><\/div>\n<h2><strong>Tree topology<\/strong><\/h2>\n<div>\n<div>The branching pattern in a tree is called <strong>tree topology. <\/strong>When all branches bifurcate on a phylogenetic tree, it is referred to as <strong>dichotomy. <\/strong>In this case, each ancestor divides and gives rise to two descendants.<\/div>\n<div>Sometimes, a branch point on a phylogenetic tree may have more than two descendents, resulting in a multifurcating node. The phylogeny with multifurcating branches is called <strong>polytomy. <\/strong>A polytomy can be a result of either an ancestral taxon giving rise to more than two immediate descendants simultaneously during evolution, a process known as radiation, or\u00a0 <span style=\"font-size: 1em\">\u00a0an unresolved phylogeny in which the exact order of bifurcations cannot be determined precisely<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div><\/div>\n<div><\/div>\n<div><img decoding=\"async\" src=\"http:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-content\/uploads\/sites\/24\/2024\/03\/Dichotomy-and-polytomy-300x136.png\" alt=\"\" width=\"300\" height=\"136\" class=\"size-medium wp-image-1653 aligncenter\" srcset=\"https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-content\/uploads\/sites\/24\/2024\/03\/Dichotomy-and-polytomy-300x136.png 300w, https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-content\/uploads\/sites\/24\/2024\/03\/Dichotomy-and-polytomy-65x29.png 65w, https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-content\/uploads\/sites\/24\/2024\/03\/Dichotomy-and-polytomy-225x102.png 225w, https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-content\/uploads\/sites\/24\/2024\/03\/Dichotomy-and-polytomy-350x158.png 350w, https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-content\/uploads\/sites\/24\/2024\/03\/Dichotomy-and-polytomy.png 559w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/div>\n<div class=\"group\/conversation-turn relative flex w-full min-w-0 flex-col agent-turn\">\n<div class=\"flex-col gap-1 md:gap-3\">\n<div class=\"flex max-w-full flex-col flex-grow\">\n<div data-message-author-role=\"assistant\" data-message-id=\"ab00fa80-f883-49e8-8d8a-cf08b58d7197\" dir=\"auto\" class=\"min-h-8 text-message flex w-full flex-col items-end gap-2 whitespace-normal break-words [.text-message+&amp;]:mt-5\" data-message-model-slug=\"gpt-4o\">\n<div class=\"flex w-full flex-col gap-1 empty:hidden first:pt-[3px]\">\n<div class=\"markdown prose w-full break-words dark:prose-invert light\">\n<p><strong>Forms of Tree Representation\u00a0<\/strong><\/p>\n<p><strong>Phylogram and Cladogram<\/strong><\/p>\n<div>The topology of branches in a tree defines the relationships between the taxa. The trees can be drawn in different ways, such as a cladogram or a phylogram.<\/div>\n<div>In a<strong> phylogram<\/strong>, the branch lengths represent the amount of evolutionary divergence. Such trees are said to be scaled.The scaled trees have the advantage of showing both the evolutionary relationships and information about the relative divergence time of the branches.<\/div>\n<div>In a <strong>cladogram<\/strong>, however, the external taxa line up neatly in a row or column. Their branch lengths are not proportional to the number of evolutionary changes and thus have no phylogenetic meaning. In such an unscaled tree, only the topology of the tree matters, which shows the relative ordering of the taxa.<\/div>\n<div><img decoding=\"async\" src=\"http:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-content\/uploads\/sites\/24\/2024\/03\/Cladogram-and-Phylogram-300x185.png\" alt=\"\" width=\"300\" height=\"185\" class=\"size-medium wp-image-1658 aligncenter\" srcset=\"https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-content\/uploads\/sites\/24\/2024\/03\/Cladogram-and-Phylogram-300x185.png 300w, https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-content\/uploads\/sites\/24\/2024\/03\/Cladogram-and-Phylogram-65x40.png 65w, https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-content\/uploads\/sites\/24\/2024\/03\/Cladogram-and-Phylogram-225x139.png 225w, https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-content\/uploads\/sites\/24\/2024\/03\/Cladogram-and-Phylogram-350x216.png 350w, https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-content\/uploads\/sites\/24\/2024\/03\/Cladogram-and-Phylogram.png 752w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/div>\n<p><strong>Molecular Phylogenetics<\/strong>:<\/p>\n<p>enables researchers to track lineages back to common ancestors by analyzing evolutionary relationships using DNA, RNA, or protein sequences.<br \/>\nMolecular techniques have transformed phylogenetics by offering information that helps elucidate connections in situations when morphological evidence is unclear or lacking.<\/p>\n<p><span style=\"font-family: 'Cormorant Garamond', serif;font-size: 1.602em\">Methods of Building Phylogenetic Trees<\/span><\/p>\n<ol>\n<li><strong>Distance Methods<\/strong>:\n<ul>\n<li>These methods create a tree based on overall similarity.These techniques determine the genetic distance between two sequence pairs.<\/li>\n<li><strong>Neighbor-joining<\/strong> is a popular distance method \u00a0that reduces the tree&#8217;s overall branch length.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Maximum Parsimony<\/strong>:\n<ul>\n<li>This approach assumes that simpler evolutionary pathways are more plausible than complex ones, and it looks for the tree with the fewest evolutionary changes.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Maximum Likelihood and Bayesian Methods<\/strong>:\n<ul>\n<li>The Bayesian and maximum likelihood statistical techniques determine the likelihood of a specific tree given an evolutionary change model.<br \/>\nWhile Bayesian approaches predict a range of plausible topologies, Maximum Likelihood uses sequence data to determine which tree has the highest likelihood.<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<h3>Applications of Phylogenetics<\/h3>\n<ol>\n<li><strong>Classification and Taxonomy<\/strong>: Contributes to the improvement of the biological categorization system by grouping species according to evolutionary links.<\/li>\n<li><strong>Understanding Evolutionary History<\/strong>: The chronology and order of evolutionary events, including speciation and trait development, can be known by an understanding of evolutionary history.<\/li>\n<li><strong>Tracking Disease Evolution<\/strong>: This method is used in epidemiology to investigate the causes and dissemination of infections, including monitoring the genetic development of viruses such as SARS-CoV-2 and HIV.<\/li>\n<li><strong>Conservation Biology<\/strong>: Assists in identifying evolutionary distinct species that, because of their distinct genetic heritage, may be conservation priorities.<\/li>\n<li><strong>Comparative Genomics<\/strong>: Phylogenetics helps to compare genomes across species, identify conserved genes, and to study gene function and evolution.<\/li>\n<\/ol>\n<\/div>\n<h2>Test your Understanding<\/h2>\n<p><span><\/p>\n<div id=\"h5p-112\">\n<div class=\"h5p-iframe-wrapper\"><iframe id=\"h5p-iframe-112\" class=\"h5p-iframe\" data-content-id=\"112\" style=\"height:1px\" src=\"about:blank\" frameBorder=\"0\" scrolling=\"no\" title=\"phylogenetic trees\"><\/iframe><\/div>\n<\/div>\n<p><\/span><\/p>\n<p>&nbsp;<\/p>\n<div class=\"markdown prose w-full break-words dark:prose-invert light\">\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"author":1,"menu_order":3,"template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"pb_show_title":"on","pb_short_title":"Phylogenetics","pb_subtitle":"Phylogenetics","pb_authors":["malathi"],"pb_section_license":"cc-by-sa"},"chapter-type":[],"contributor":[62],"license":[54],"class_list":["post-309","chapter","type-chapter","status-publish","hentry","contributor-malathi","license-cc-by-sa"],"aioseo_notices":[],"part":61,"_links":{"self":[{"href":"https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-json\/pressbooks\/v2\/chapters\/309","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-json\/pressbooks\/v2\/chapters"}],"about":[{"href":"https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-json\/wp\/v2\/types\/chapter"}],"author":[{"embeddable":true,"href":"https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":24,"href":"https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-json\/pressbooks\/v2\/chapters\/309\/revisions"}],"predecessor-version":[{"id":1714,"href":"https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-json\/pressbooks\/v2\/chapters\/309\/revisions\/1714"}],"part":[{"href":"https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-json\/pressbooks\/v2\/parts\/61"}],"metadata":[{"href":"https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-json\/pressbooks\/v2\/chapters\/309\/metadata\/"}],"wp:attachment":[{"href":"https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-json\/wp\/v2\/media?parent=309"}],"wp:term":[{"taxonomy":"chapter-type","embeddable":true,"href":"https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-json\/pressbooks\/v2\/chapter-type?post=309"},{"taxonomy":"contributor","embeddable":true,"href":"https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-json\/wp\/v2\/contributor?post=309"},{"taxonomy":"license","embeddable":true,"href":"https:\/\/pressbooks.justwrite.in\/interactive-biology-secondary\/wp-json\/wp\/v2\/license?post=309"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}